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JEUNESSEInc. Institute of Longevity Medicine 11/5/99
Background and rationale: Cancer is the second leading cause of death in the US. The rate of nearly every type of cancer is on the rise. Despite billions of dollars in research, the mortality rate has remained virtually unchanged since the 1960's using conventional treatments such as radiation, surgery, and chemotherapy. Thus, there is considerable interest in using immune modulation as an adjuvant for cancer therapy. Natural killer cells are particularly important in destroying cancer cells. Purpose of study: To determine the in vitro anti-cancer effects of Transfer FactorÔ and Transfer Factor PlusÔ using PBMC isolated from human volunteers and assaying the increased ability of the NK cell population to kill K562 erythroleukemic cells. Methods: 	1) PBMC killing of K562 (erythroleukemic) cells Results:	2) Transfer Factor increased NK-cell killing by 103% and 		Transfer Factor PlusÔ by 248% Conclusions: Transfer FactorÔ and Transfer Factor PlusÔ induced immune-based lysis of K562 cells at a level unprecedented in the director's experience or in the known medical literature. Since NK cell function is so crucial in killing cancer cells, these products are ideal candidates for cancer adjuvant therapy. In addition, NK cells form a first line of defense against infections from viruses and certain other microorganisms. Killing assays against K562 cells have also been correlated with increased activity against chronic and acute infections as well.
Darryl See, M.D. Transfer Factor Study (4Life) N.K. Assay, October 27, 1999
Transfer Factor Plus Study (4Life) N.K. Assay	 November 4,1999
Transfer Factor and Transfer Factor Plus Study (4Life) Toxicity Assay November 9, 1999
Nutraceutical Induced Increase in
Purpose of Study: To determine the in vitro Natural Killer Cell (NK) activation effects of 4 Life Transfer Factor and Transfer Factor Plus using peripheral blood mononuclear cells (PBMC) isolated from human volunteers and assaying the increased ability of the NK cell population to kill K562 erthroleukemic cells.
Baseline activity is the measure of the unassisted ability of white blood cells to kill K562 leukemia (cancer) cells. Natural Killer Cells are the body's first line of defense against cancers and viruses. The increase in the ability of white blood cells to kill K562 cancer cells is directly related to the increase in Natural Killer Cell activity. This study does not claim nor should it be interpreted to cure, prevent or mitigate any serious disease. The results have been reported as they were received. If you have a serious Mess, see Your health professional before beginning any new regimen
Understanding the Immune System Natural Killer Cells
Both cytotoxic T cells and natural killer cells kill on contact. The killer binds to its target, aims its weapons, and then delivers a lethal burst of chemicals that produces holes in the target cell's membrane. Fluids seep in and leak out, and the cell bursts.
NATURAL KILLER CELLS The following links provide information on research related to natural killer cells - one of the main types of white blood cells which work as part of the human immune system. Natural killer cells are being found to play a primary role in preventing and removing cancer cells in the body, removing many types of viruses (including herpes and measles) and have been found low in women with endometriosis. Of great concern is the fact that many common chemical sources are being found to damage, weaken and lower natural killer cell function and numbers. We have located medical journal articles on natural killer cell function and have summarized these for you below. Click on any link below for more information on natural killer cells. This site is currently under construction so please be patient as information is added. Thank you!
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Natural Killer (NK) cells are yet
another type of lethal lymphocyte. Like cytotoxic T cells, they contain granules
filled with potent chemicals. They are called "natural" killers because
they, unlike cytotoxic T cells, do not need to recognize a specific antigen before
swinging into action. They target tumor cells and protect against a wide variety
of infectious microbes. In several immunodeficiency diseases, including AIDS, natural
killer cell function is abnormal. Natural killer cells may also contribute to immunoregulation
by secreting high levels of influential lymphokines.